What does Psalm 55:22 mean?

David wisely advises anyone hearing or reading this song to put all their trust in the Lord. To "cast your burden" means to fully entrust it to God, rather than trying to carry it yourself. Regardless of the situation, God is more capable than any human being ever could be. David understood what happens when a believer releases his worries and fears into the care of the Lord: God takes on that weight. That does not make believers immune to tragedy or hardship (Proverbs 24:1–2; John 16:33). It means nothing can happen to God's people which is not for ultimate good and His glory (Romans 8:28).

The apostle Peter offers the same counsel in 1 Peter 5:7, saying, "[cast] all your anxieties on [God], because he cares for you." Paul gave similar advice; he recommended prayer as the remedy for whatever concerns the Christian. He writes: "Do not be anxious about anything, but in everything by prayer and supplication with thanksgiving let your requests be made known to God. And the peace of God, which surpasses all understanding, will guard your hearts and your minds in Christ Jesus" (Philippians 4:6–7).