What does Psalm 139:10 mean?
The prior verse affirmed God would be present, even in the far reaches of the Mediterranean Sea, to guide and protect (Psalm 139:9). Isaiah 58:11 promises God's people, "The LORD will guide you continually and satisfy your desire in scorched places and make your bones strong; and you shall be like a watered garden, like a spring of water, whose waters do not fail."God is with believers today, as well. He offers to guide us and take care of us. Jesus identified Himself as the Good Shepherd. As such, He differs from false shepherds who neither care for nor protect the sheep (John 10:1, 10, 12–13). By contrast, Jesus the Good Shepherd leads His sheep (John 10:3). He goes before them to show the way and to protect them (John 10:4). Later in John 10 Jesus spoke further of His protection of believers. He said in verse 28: "I give them eternal life, and they will never perish, and no one will snatch them out of my hand" (John 10:28).
Psalm 139:7–12 follows a passage focused on God's omniscience. This section of the psalm describes His omnipresence: His ability to be everywhere at once. David mentions some of the places he might go, only to discover that God is there. The knowledge of God's presence comforted David. He knew God would be with him everywhere he went.
In this psalm David marvels at God's amazing characteristics. God knows everything about him: where he goes, all David's thoughts and everything about his conduct. The Lord knows what David will say even before David says it. There is no place David can go that God isn't already present. David marvels at God's creative work in the womb. He is thankful for God's innumerable thoughts for him and for God's presence day and night. Finally, David's thoughts turn to the wicked. He considers them God's enemies and his, and longs for God to slay them. David is disgusted by evil people because they rail against God and take His name in vain. He asks God to search his heart to see if any sin is there, and he asks God to lead him in the way everlasting.