What does Genesis 27:44 mean?

Rebekah overheard Isaac's plan to bless Esau, and hatched a plot to help Jacob steal it (Genesis 27:1–6). She herself concocted a disguise and compelled Jacob to use it (Genesis 27:7–17). That resulted in a successful deception (Genesis 27:30–35), but it also drove Esau into a murderous rage (Genesis 27:41). Once again, Rebekah manages to come across valuable information. She has heard of Esau's plan to kill Jacob for stealing away the blessing Isaac had intended to give to him. Now she is commanding Jacob to run away to her brother Laban's household in Mesopotamia (Genesis 24:1–4; 23–28). She wants Jacob to stay there until Esau cools down, until his murderous rage passes.

She doesn't suggest how long that might take. Given how much she favors Jacob (Genesis 25:28), she probably does not realize that this will be, essentially, a permanent goodbye. She intends to call Jacob back some day. However, once Jacob flees, he will not return until after Rebekah has died (Genesis 35:27; 49:31). Her deception might have obtained a blessing for her son, but it cost her dearly.