What does Proverbs 1:25 mean?

Prior verses have described the offer of wisdom given to all people. Wisdom is imagined as a woman calling out in a crowded, public place. The only way to avoid her is to ignore her. Those who listen will be blessed. Unfortunately, as seen in verse 22, many people purposefully choose ignorance. Many people in the world "would rather not know."

Verse 25 gives a deeper sense of this rebellion. Those who turn away from wisdom are not simply choosing another path. They are ignoring—disregarding, or neglecting—her advice, deliberately choosing not to consider what she says. The phrase "would have none of" it, as in the ESV and NKJV, is very descriptive. When a person insists on rejecting every single part of a message, we say they are "having none of it."

Those who are ignoring wisdom, according to this passage, are like those described in verse 18. They have already started down the path of wickedness, and they refuse to hear anything from wisdom to turn them from sin.