What does 1 Timothy 5:21 mean?
ESV: In the presence of God and of Christ Jesus and of the elect angels I charge you to keep these rules without prejudging, doing nothing from partiality.
NIV: I charge you, in the sight of God and Christ Jesus and the elect angels, to keep these instructions without partiality, and to do nothing out of favoritism.
NASB: I solemnly exhort you in the presence of God and of Christ Jesus and of His chosen angels, to maintain these principles without bias, doing nothing in a spirit of partiality.
CSB: I solemnly charge you before God and Christ Jesus and the elect angels to observe these things without prejudice, doing nothing out of favoritism.
NLT: I solemnly command you in the presence of God and Christ Jesus and the highest angels to obey these instructions without taking sides or showing favoritism to anyone.
KJV: I charge thee before God, and the Lord Jesus Christ, and the elect angels, that thou observe these things without preferring one before another, doing nothing by partiality.
NKJV: I charge you before God and the Lord Jesus Christ and the elect angels that you observe these things without prejudice, doing nothing with partiality.
Verse Commentary:
In verse 19, Paul described a requirement that accusations against an elder come only from two or three witnesses. Here Paul reflects this gravity by referring to three "witnesses" to his command to Timothy. The seriousness, therefore, cannot be higher. In this case, should he fail, the "witnesses" against Timothy would be God the Father, Jesus, and the angels themselves.

Paul's command to Timothy is to not back down or be timid regarding enforcement of rebuking and removing sinning elders. This would likely be the most difficult work he would face as a church leader, but Paul emphasized that it must be done. The phrase "without prejudging" is the idea of without bias, meaning Timothy couldn't favor elders he liked or more harshly judge those he did not like; he had to deal with the evidence and facts of each situation. This, also, harmonizes with the need to only pursue accusations where there is sufficient evidence.

In dealing with elders, Timothy could do "nothing from partiality." False teachers showed favoritism (Jude 1:16), but Timothy could not. Christians are not to show favoritism of any kind: "My brothers, show no partiality as you hold the faith in our Lord Jesus Christ, the Lord of glory" (James 2:1), including in dealings with church leaders.
Verse Context:
First Timothy 5:17–25 provides guidelines on how a church should honor elders. It also refers to the proper way to discipline them, if this becomes necessary. Those who devote themselves to serving the church should be supported, meaning paid, so they can fully focus on the needs of the congregation. Accusations should only be taken seriously when there is sufficient evidence. And elders who are found in sin should be publicly rebuked. Paul also warns Timothy not to be too hasty in assigning elders, since some men's sins are hidden and hard to detect.
Chapter Summary:
First Timothy chapter 5 focuses on Timothy's supervision of those within the church. This includes a respectful attitude towards both men and women, young and old. A large portion of the chapter deals with how to care for widows. The theme of Paul's instruction is prioritizing those who are truly in need, and not enabling those who are merely lazy. Timothy is also instructed on how to screen out baseless accusations against an elder, and how to properly discipline them if they are found in sin. With that in mind, Timothy is also warned not to be reckless in who he appoints as an elder.
Chapter Context:
Prior passages explained the burden placed on Timothy and other church leaders. In this chapter, the emphasis is on how Timothy is to treat others in the congregation. A large portion of this refers to prioritizing charity for widows. This passage will more or less complete Paul's specific instructions to Timothy in this letter. The next (final) chapter will build on all of these themes with a command for Timothy to make the most of his spiritual service.
Book Summary:
First Timothy is one of Paul's three ''Pastoral Epistles.'' Paul's other letters, such as Romans, Ephesians, and Colossians, are meant for a broader audience. First Timothy, 2 Timothy, and Titus are written to specific people whom Paul is advising on how to best lead their local churches. These three letters present a close look at the form and function of church leadership. First Timothy, like 2 Timothy and Titus, is less formal and systematic, and more personal. This gives great insight into the way pastors, deacons, and elders ought to prioritize their time and energy.
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